Drug interactions
Bremelanotide + Phenobarbital
Severity: Minor
Bremelanotide and Phenobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bremelanotide can slow gastric emptying, which may delay or slightly reduce absorption of oral phenobarbital. Phenobarbital has a long half-life and is usually dosed to steady state, so the clinical effect is generally small, though a transient change could matter for seizure control.
What this interaction means in plain words
Bremelanotide and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Delayed gastric emptying from bremelanotide may reduce the rate and possibly the extent of oral phenobarbital absorption.
What to do
No routine change is needed for patients on stable phenobarbital therapy. Monitor seizure control, and check serum phenobarbital levels if breakthrough seizures occur after starting bremelanotide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bremelanotide and Phenobarbital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bremelanotide
- Bremelanotide + Bupropion-naltrexone Moderate
- Bremelanotide + Cyclosporin Moderate
- Bremelanotide + Digoxin Moderate
- Bremelanotide + Disopyramide Moderate
- Bremelanotide + Naltrexone Moderate
- Bremelanotide + Procainamide Moderate
Frequently asked questions
Can I take Bremelanotide with Phenobarbital?
MediHelp rates the interaction as minor. Bremelanotide and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bremelanotide can slow gastric emptying, which may delay or slightly reduce absorption of oral phenobarbital. Phenobarbital has a long half-life and is usually dosed to steady state, so the clinical effect is generally small, though a transient change could matter for seizure control.
How serious is the interaction between Bremelanotide and Phenobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for patients on stable phenobarbital therapy. Monitor seizure control, and check serum phenobarbital levels if breakthrough seizures occur after starting bremelanotide.
What other medicines interact with Bremelanotide?
MediHelp also lists interactions of Bremelanotide with, for example, Bupropion-naltrexone, Cyclosporin, Digoxin. The full list is on the Bremelanotide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
