Drug interactions
Brensocatib + Clarithromycin
Severity: Minor
Brensocatib and Clarithromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin increases brensocatib exposure by a modest amount (about 55% in AUC). This is unlikely to be clinically important for most patients.
What this interaction means in plain words
Brensocatib and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brensocatib belongs to Miscellaneous; Clarithromycin belongs to Anti Bacterial.
Why it happens
Clarithromycin inhibits CYP3A4 and P-glycoprotein, reducing brensocatib clearance.
What to do
No dose adjustment is generally needed; monitor for brensocatib adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brensocatib
- Brensocatib + Rifampicin Minor
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Brensocatib with Clarithromycin?
MediHelp rates the interaction as minor. Brensocatib and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin increases brensocatib exposure by a modest amount (about 55% in AUC). This is unlikely to be clinically important for most patients.
How serious is the interaction between Brensocatib and Clarithromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for brensocatib adverse effects.
What other medicines interact with Brensocatib?
MediHelp also lists interactions of Brensocatib with, for example, Rifampicin. The full list is on the Brensocatib page.
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