Drug interactions
Brentuximab + Erdafitinib
Severity: Moderate
Brentuximab and Erdafitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein, and brentuximab vedotin's cytotoxic component MMAE is a P-gp substrate. Higher MMAE exposure could increase toxicities such as neutropenia and peripheral neuropathy. The clinical significance has not been well studied.
What this interaction means in plain words
Brentuximab and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Erdafitinib belongs to Oncology.
Why it happens
Erdafitinib inhibits P-gp efflux, potentially raising exposure to MMAE released from brentuximab vedotin.
What to do
Monitor blood counts and for peripheral neuropathy and infection. Consider dose modification of brentuximab vedotin if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Brentuximab with Erdafitinib?
MediHelp rates the interaction as moderate. Brentuximab and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein, and brentuximab vedotin's cytotoxic component MMAE is a P-gp substrate. Higher MMAE exposure could increase toxicities such as neutropenia and peripheral neuropathy. The clinical significance has not been well studied.
How serious is the interaction between Brentuximab and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for peripheral neuropathy and infection. Consider dose modification of brentuximab vedotin if toxicity appears.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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