Drug interactions
Brentuximab + Ivosidenib
Severity: Moderate
Brentuximab and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4, and MMAE released from brentuximab vedotin is a CYP3A4 substrate. Lower MMAE exposure could theoretically reduce efficacy. Ivosidenib can also prolong the QT interval, but this is not directly relevant to this pairing.
What this interaction means in plain words
Brentuximab and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Ivosidenib belongs to Oncology.
Why it happens
CYP3A4 induction by ivosidenib may increase MMAE clearance.
What to do
Monitor for reduced response to brentuximab vedotin. Use an alternative if the loss of effect is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Brentuximab with Ivosidenib?
MediHelp rates the interaction as moderate. Brentuximab and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4, and MMAE released from brentuximab vedotin is a CYP3A4 substrate. Lower MMAE exposure could theoretically reduce efficacy. Ivosidenib can also prolong the QT interval, but this is not directly relevant to this pairing.
How serious is the interaction between Brentuximab and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to brentuximab vedotin. Use an alternative if the loss of effect is a concern.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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