Drug interactions
Brentuximab + Ketoconazole
Severity: Moderate
Brentuximab and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole, a strong CYP3A4 inhibitor, increases MMAE exposure from brentuximab vedotin as shown in labeled pharmacokinetic studies. This raises the risk of neutropenia and other toxicities.
What this interaction means in plain words
Brentuximab and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Ketoconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition decreases MMAE clearance.
What to do
Monitor closely for neutropenia and other adverse reactions, with dose interruption or delay if they occur. Prefer a non-inhibiting antifungal where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Brentuximab with Ketoconazole?
MediHelp rates the interaction as moderate. Brentuximab and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole, a strong CYP3A4 inhibitor, increases MMAE exposure from brentuximab vedotin as shown in labeled pharmacokinetic studies. This raises the risk of neutropenia and other toxicities.
How serious is the interaction between Brentuximab and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia and other adverse reactions, with dose interruption or delay if they occur. Prefer a non-inhibiting antifungal where possible.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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