Drug interactions
Brentuximab + Sotorasib
Severity: Moderate
Brentuximab and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inhibitor that raises exposure of P-gp substrates, such as digoxin. MMAE from brentuximab vedotin is a P-gp substrate, so its exposure could increase and lead to more neutropenia and neuropathy. The legacy direction of a decrease is not mechanistically supported.
What this interaction means in plain words
Brentuximab and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
P-gp inhibition by sotorasib may increase MMAE exposure.
What to do
Monitor blood counts and for neuropathy. Adjust or hold brentuximab if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Brentuximab with Sotorasib?
MediHelp rates the interaction as moderate. Brentuximab and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-gp inhibitor that raises exposure of P-gp substrates, such as digoxin. MMAE from brentuximab vedotin is a P-gp substrate, so its exposure could increase and lead to more neutropenia and neuropathy. The legacy direction of a decrease is not mechanistically supported.
How serious is the interaction between Brentuximab and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neuropathy. Adjust or hold brentuximab if toxicity occurs.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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