Drug interactions
Brentuximab vedotin + Efavirenz
Severity: Minor
Brentuximab vedotin and Efavirenz: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz is a CYP3A4 inducer and may lower exposure to MMAE, the cytotoxic component released from brentuximab vedotin. The clinical effect is likely small because MMAE is only partly cleared by CYP3A4, but efficacy could theoretically be reduced.
What this interaction means in plain words
Brentuximab vedotin and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brentuximab vedotin belongs to Oncology; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induces CYP3A4, which metabolizes the released cytotoxic payload MMAE.
What to do
No dose adjustment is generally needed; monitor response to lymphoma therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicated
- Brentuximab vedotin + Siponimod Major
- Apalutamide + Brentuximab vedotin Moderate
- Brentuximab vedotin + Clarithromycin Moderate
- Brentuximab vedotin + Imatinib Moderate
- Brentuximab vedotin + Isoniazid Moderate
Frequently asked questions
Can I take Brentuximab vedotin with Efavirenz?
MediHelp rates the interaction as minor. Brentuximab vedotin and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz is a CYP3A4 inducer and may lower exposure to MMAE, the cytotoxic component released from brentuximab vedotin. The clinical effect is likely small because MMAE is only partly cleared by CYP3A4, but efficacy could theoretically be reduced.
How serious is the interaction between Brentuximab vedotin and Efavirenz?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor response to lymphoma therapy.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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