Drug interactions
Brentuximab vedotin + Oxcarbazepine
Severity: Minor
Brentuximab vedotin and Oxcarbazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brentuximab vedotin releases the toxin MMAE, which is a CYP3A4 substrate. Oxcarbazepine could lower MMAE exposure, but the effect is likely modest and not clearly clinically important.
What this interaction means in plain words
Brentuximab vedotin and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brentuximab vedotin belongs to Oncology; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by oxcarbazepine may modestly increase MMAE clearance.
What to do
No dose change is needed; monitor treatment response as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicated
- Brentuximab vedotin + Siponimod Major
- Apalutamide + Brentuximab vedotin Moderate
- Brentuximab vedotin + Clarithromycin Moderate
- Brentuximab vedotin + Imatinib Moderate
- Brentuximab vedotin + Isoniazid Moderate
Frequently asked questions
Can I take Brentuximab vedotin with Oxcarbazepine?
MediHelp rates the interaction as minor. Brentuximab vedotin and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brentuximab vedotin releases the toxin MMAE, which is a CYP3A4 substrate. Oxcarbazepine could lower MMAE exposure, but the effect is likely modest and not clearly clinically important.
How serious is the interaction between Brentuximab vedotin and Oxcarbazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor treatment response as usual.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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