Drug interactions
Brentuximab vedotin + Tabelecleucel
Severity: Moderate
Brentuximab vedotin and Tabelecleucel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brentuximab vedotin is cytotoxic to CD30-positive cells and may impair the activity or survival of infused T cells. This could reduce tabelecleucel efficacy.
What this interaction means in plain words
Brentuximab vedotin and Tabelecleucel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Tabelecleucel belongs to Oncology.
Why it happens
Cytotoxic and immunomodulatory effects of brentuximab vedotin may damage the infused EBV-specific T cells.
What to do
Allow an adequate washout after brentuximab vedotin before giving tabelecleucel, following the product labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tabelecleucel
- Prednisone + Tabelecleucel Moderate
Other interactions of Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicated
- Brentuximab vedotin + Siponimod Major
- Apalutamide + Brentuximab vedotin Moderate
- Brentuximab vedotin + Clarithromycin Moderate
- Brentuximab vedotin + Imatinib Moderate
- Brentuximab vedotin + Isoniazid Moderate
Frequently asked questions
Can I take Brentuximab vedotin with Tabelecleucel?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Tabelecleucel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brentuximab vedotin is cytotoxic to CD30-positive cells and may impair the activity or survival of infused T cells. This could reduce tabelecleucel efficacy.
How serious is the interaction between Brentuximab vedotin and Tabelecleucel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Allow an adequate washout after brentuximab vedotin before giving tabelecleucel, following the product labeling.
What other medicines interact with Tabelecleucel?
MediHelp also lists interactions of Tabelecleucel with, for example, Prednisone. The full list is on the Tabelecleucel page.
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