Drug interactions
Brentuximab vedotin + Trastuzumab
Severity: Moderate
Brentuximab vedotin and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brentuximab vedotin commonly causes neutropenia, and trastuzumab given with myelosuppressive agents has been associated with more neutropenia and febrile neutropenia. Using both may raise the risk of serious infection.
What this interaction means in plain words
Brentuximab vedotin and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression, mainly from the cytotoxic payload of brentuximab vedotin, on top of the neutropenia seen with trastuzumab plus chemotherapy.
What to do
Monitor complete blood counts regularly and check for signs of infection. Consider G-CSF support or dose adjustment of brentuximab vedotin if significant neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicated
- Brentuximab vedotin + Siponimod Major
- Apalutamide + Brentuximab vedotin Moderate
- Brentuximab vedotin + Clarithromycin Moderate
- Brentuximab vedotin + Imatinib Moderate
- Brentuximab vedotin + Isoniazid Moderate
Frequently asked questions
Can I take Brentuximab vedotin with Trastuzumab?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brentuximab vedotin commonly causes neutropenia, and trastuzumab given with myelosuppressive agents has been associated with more neutropenia and febrile neutropenia. Using both may raise the risk of serious infection.
How serious is the interaction between Brentuximab vedotin and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and check for signs of infection. Consider G-CSF support or dose adjustment of brentuximab vedotin if significant neutropenia develops.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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