Drug interactions
Bretylium + Losartan
Severity: Moderate
Bretylium and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium can cause marked hypotension through adrenergic neuron blockade. Combined with losartan, hypotension can be more severe, especially in patients who are volume depleted.
What this interaction means in plain words
Bretylium and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects through sympathetic blockade and angiotensin receptor blockade.
What to do
Monitor blood pressure continuously while bretylium is given. Reduce or hold losartan if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Bretylium with Losartan?
MediHelp rates the interaction as moderate. Bretylium and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium can cause marked hypotension through adrenergic neuron blockade. Combined with losartan, hypotension can be more severe, especially in patients who are volume depleted.
How serious is the interaction between Bretylium and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously while bretylium is given. Reduce or hold losartan if hypotension develops.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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