Drug interactions
Bretylium + Nitroglycerin
Severity: Moderate
Bretylium and Nitroglycerin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause hypotension, and bretylium impairs sympathetic reflex compensation. Concurrent use with nitroglycerin may therefore cause pronounced or orthostatic hypotension.
What this interaction means in plain words
Bretylium and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects of nitrate venodilation and bretylium-induced adrenergic neuron blockade.
What to do
Monitor blood pressure and heart rate closely and titrate nitroglycerin to effect. Keep patients supine during initiation and correct volume depletion first.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
Frequently asked questions
Can I take Bretylium with Nitroglycerin?
MediHelp rates the interaction as moderate. Bretylium and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause hypotension, and bretylium impairs sympathetic reflex compensation. Concurrent use with nitroglycerin may therefore cause pronounced or orthostatic hypotension.
How serious is the interaction between Bretylium and Nitroglycerin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely and titrate nitroglycerin to effect. Keep patients supine during initiation and correct volume depletion first.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
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