Drug interactions
Brexanolone + Clorazepate
Severity: Major
Brexanolone and Clorazepate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone infusion causes excessive sedation and sudden loss of consciousness in some patients, and other CNS depressants may add to this. Concurrent clorazepate may raise the risk of oversedation.
What this interaction means in plain words
Brexanolone and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive GABA-A receptor modulation, as brexanolone is a neuroactive steroid positive modulator.
What to do
Monitor continuously with pulse oximetry and sedation assessment during the infusion. Reduce or hold the benzodiazepine or the infusion if excessive sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Brexanolone with Clorazepate?
MediHelp rates the interaction as major. Brexanolone and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone infusion causes excessive sedation and sudden loss of consciousness in some patients, and other CNS depressants may add to this. Concurrent clorazepate may raise the risk of oversedation.
How serious is the interaction between Brexanolone and Clorazepate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously with pulse oximetry and sedation assessment during the infusion. Reduce or hold the benzodiazepine or the infusion if excessive sedation occurs.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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