Drug interactions
Brexanolone + Flibanserin
Severity: Major
Brexanolone and Flibanserin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both cause sedation, and together may produce excessive sleepiness, loss of consciousness and hypotension.
What this interaction means in plain words
Brexanolone and Flibanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation and oxygen saturation during infusion, and avoid flibanserin during brexanolone treatment or reduce doses if sedation appears.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Brexanolone with Flibanserin?
MediHelp rates the interaction as major. Brexanolone and Flibanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both cause sedation, and together may produce excessive sleepiness, loss of consciousness and hypotension.
How serious is the interaction between Brexanolone and Flibanserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation during infusion, and avoid flibanserin during brexanolone treatment or reduce doses if sedation appears.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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