Drug interactions
Brexanolone + Fluphenazine
Severity: Moderate
Brexanolone and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes dose-related sedation and loss of consciousness, and fluphenazine adds to CNS depression. Combined use may cause excessive sedation.
What this interaction means in plain words
Brexanolone and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation and oxygen saturation during infusion. Reduce or interrupt the brexanolone infusion if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Brexanolone with Fluphenazine?
MediHelp rates the interaction as moderate. Brexanolone and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes dose-related sedation and loss of consciousness, and fluphenazine adds to CNS depression. Combined use may cause excessive sedation.
How serious is the interaction between Brexanolone and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation during infusion. Reduce or interrupt the brexanolone infusion if excessive sedation occurs.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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