Drug interactions
Brexanolone + Haloperidol
Severity: Moderate
Brexanolone and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness, and other CNS depressants such as haloperidol may add to this effect. Concurrent use may require infusion dose changes.
What this interaction means in plain words
Brexanolone and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A modulation and antipsychotic sedation.
What to do
Monitor sedation and oxygen saturation continuously during infusion. Interrupt or reduce the brexanolone infusion if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Brexanolone with Haloperidol?
MediHelp rates the interaction as moderate. Brexanolone and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes excessive sedation and sudden loss of consciousness, and other CNS depressants such as haloperidol may add to this effect. Concurrent use may require infusion dose changes.
How serious is the interaction between Brexanolone and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation continuously during infusion. Interrupt or reduce the brexanolone infusion if excessive sedation occurs.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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