Drug interactions
Brexanolone + Perphenazine
Severity: Moderate
Brexanolone and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness in some patients, and perphenazine adds CNS depression. Combined use can deepen sedation and increase the risk of falls or respiratory compromise.
What this interaction means in plain words
Brexanolone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A modulation and phenothiazine sedation.
What to do
Monitor continuously for sedation and hypoxia with pulse oximetry during the infusion. Reduce or interrupt the infusion if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Brexanolone with Perphenazine?
MediHelp rates the interaction as moderate. Brexanolone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes excessive sedation and sudden loss of consciousness in some patients, and perphenazine adds CNS depression. Combined use can deepen sedation and increase the risk of falls or respiratory compromise.
How serious is the interaction between Brexanolone and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously for sedation and hypoxia with pulse oximetry during the infusion. Reduce or interrupt the infusion if excessive sedation occurs.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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