Drug interactions
Brexpiprazole + Butorphanol
Severity: Moderate
Brexpiprazole and Butorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole can cause somnolence, and combined with an opioid sedation and dizziness may increase. This can impair driving and raise fall risk.
What this interaction means in plain words
Brexpiprazole and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Butorphanol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and antipsychotic receptor activity.
What to do
Monitor for oversedation and orthostasis, particularly during initiation or titration. Consider a lower butorphanol dose if drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Butorphanol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Butorphanol?
MediHelp rates the interaction as moderate. Brexpiprazole and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole can cause somnolence, and combined with an opioid sedation and dizziness may increase. This can impair driving and raise fall risk.
How serious is the interaction between Brexpiprazole and Butorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostasis, particularly during initiation or titration. Consider a lower butorphanol dose if drowsiness occurs.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
