Drug interactions
Brexpiprazole + Cenobamate
Severity: Moderate
Brexpiprazole and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4, which can lower brexpiprazole concentrations and reduce its effectiveness. Both drugs also cause somnolence, so sedation may be additive.
What this interaction means in plain words
Brexpiprazole and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Cenobamate belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by cenobamate increases brexpiprazole clearance, along with additive CNS depression.
What to do
Monitor clinical response and consider increasing the brexpiprazole dose when cenobamate is started, reducing it again if cenobamate is stopped. Monitor for sedation and dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Cenobamate
Frequently asked questions
Can I take Brexpiprazole with Cenobamate?
MediHelp rates the interaction as moderate. Brexpiprazole and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4, which can lower brexpiprazole concentrations and reduce its effectiveness. Both drugs also cause somnolence, so sedation may be additive.
How serious is the interaction between Brexpiprazole and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider increasing the brexpiprazole dose when cenobamate is started, reducing it again if cenobamate is stopped. Monitor for sedation and dizziness.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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