Drug interactions
Brexpiprazole + Chlordiazepoxide
Severity: Moderate
Brexpiprazole and Chlordiazepoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness, so combined use may amplify sedation and impair alertness and coordination. The risk is higher in older patients.
What this interaction means in plain words
Brexpiprazole and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Chlordiazepoxide belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and brexpiprazole's antihistaminic and antiadrenergic activity.
What to do
Monitor for excessive sedation and falls, and use the lowest effective doses. Counsel on driving and alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Chlordiazepoxide?
MediHelp rates the interaction as moderate. Brexpiprazole and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause drowsiness, so combined use may amplify sedation and impair alertness and coordination. The risk is higher in older patients.
How serious is the interaction between Brexpiprazole and Chlordiazepoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and falls, and use the lowest effective doses. Counsel on driving and alcohol avoidance.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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