Drug interactions
Brexpiprazole + Dabrafenib
Severity: Moderate
Brexpiprazole and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and can lower brexpiprazole concentrations. This may lead to loss of psychiatric symptom control.
What this interaction means in plain words
Brexpiprazole and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, increasing the metabolism of brexpiprazole.
What to do
Monitor clinical response and consider doubling the brexpiprazole dose over 1 to 2 weeks. Return to the usual dose when dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Dabrafenib
Frequently asked questions
Can I take Brexpiprazole with Dabrafenib?
MediHelp rates the interaction as moderate. Brexpiprazole and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and can lower brexpiprazole concentrations. This may lead to loss of psychiatric symptom control.
How serious is the interaction between Brexpiprazole and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider doubling the brexpiprazole dose over 1 to 2 weeks. Return to the usual dose when dabrafenib is stopped.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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