Drug interactions
Brexpiprazole + Darifenacin
Severity: Moderate
Brexpiprazole and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is a moderate CYP2D6 inhibitor, and brexpiprazole is cleared by CYP2D6 and CYP3A4. Darifenacin may raise brexpiprazole exposure, with greater risk if a CYP3A4 inhibitor is also given or the patient is a CYP2D6 poor metabolizer.
What this interaction means in plain words
Brexpiprazole and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Darifenacin belongs to Genitourinary.
Why it happens
Inhibition of CYP2D6-mediated metabolism of brexpiprazole by darifenacin.
What to do
Monitor for brexpiprazole adverse effects such as akathisia and sedation, and reduce the dose if combined with a CYP3A4 inhibitor, following labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Darifenacin?
MediHelp rates the interaction as moderate. Brexpiprazole and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darifenacin is a moderate CYP2D6 inhibitor, and brexpiprazole is cleared by CYP2D6 and CYP3A4. Darifenacin may raise brexpiprazole exposure, with greater risk if a CYP3A4 inhibitor is also given or the patient is a CYP2D6 poor metabolizer.
How serious is the interaction between Brexpiprazole and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for brexpiprazole adverse effects such as akathisia and sedation, and reduce the dose if combined with a CYP3A4 inhibitor, following labeling.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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