Drug interactions
Brexpiprazole + Diazepam intranasal
Severity: Moderate
Brexpiprazole and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use can potentiate sedation, dizziness and psychomotor impairment, and benzodiazepines with antipsychotics may add to respiratory depression risk at high doses. Orthostatic hypotension may also be additive.
What this interaction means in plain words
Brexpiprazole and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A enhancement plus antipsychotic sedative and antihistaminic/alpha-blocking effects.
What to do
Monitor sedation level and respiratory status, especially after rescue doses. Limit the benzodiazepine dose to what is needed and advise against driving afterward.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Diazepam intranasal?
MediHelp rates the interaction as moderate. Brexpiprazole and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use can potentiate sedation, dizziness and psychomotor impairment, and benzodiazepines with antipsychotics may add to respiratory depression risk at high doses. Orthostatic hypotension may also be additive.
How serious is the interaction between Brexpiprazole and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status, especially after rescue doses. Limit the benzodiazepine dose to what is needed and advise against driving afterward.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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