Drug interactions
Brexpiprazole + Disulfiram
Severity: Moderate
Brexpiprazole and Disulfiram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram may inhibit CYP2D6 and raise brexpiprazole levels. The increase is likely modest alone but larger if CYP3A4 inhibitors are also present.
What this interaction means in plain words
Brexpiprazole and Disulfiram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Disulfiram inhibits CYP2D6, reducing brexpiprazole metabolism.
What to do
Monitor for brexpiprazole adverse effects such as akathisia and sedation. Reduce the dose if both CYP2D6 and CYP3A4 inhibitors are in use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Disulfiram?
MediHelp rates the interaction as moderate. Brexpiprazole and Disulfiram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disulfiram may inhibit CYP2D6 and raise brexpiprazole levels. The increase is likely modest alone but larger if CYP3A4 inhibitors are also present.
How serious is the interaction between Brexpiprazole and Disulfiram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for brexpiprazole adverse effects such as akathisia and sedation. Reduce the dose if both CYP2D6 and CYP3A4 inhibitors are in use.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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