Drug interactions
Brexpiprazole + Esketamine intranasal
Severity: Moderate
Brexpiprazole and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and dizziness, and esketamine also impairs cognition and can raise blood pressure. Taken together, the central nervous system effects may be additive.
What this interaction means in plain words
Brexpiprazole and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant effects; no pharmacokinetic interaction is established.
What to do
Monitor sedation and blood pressure during and after esketamine dosing, observing the patient for the full session period. Counsel patients not to drive until the next day after a restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Esketamine intranasal?
MediHelp rates the interaction as moderate. Brexpiprazole and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and dizziness, and esketamine also impairs cognition and can raise blood pressure. Taken together, the central nervous system effects may be additive.
How serious is the interaction between Brexpiprazole and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during and after esketamine dosing, observing the patient for the full session period. Counsel patients not to drive until the next day after a restful sleep.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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