Drug interactions
Brexpiprazole + Fentanyl intranasal
Severity: Major
Brexpiprazole and Fentanyl intranasal: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal fentanyl with brexpiprazole can cause additive sedation and respiratory depression. Cognitive and psychomotor impairment may also be amplified.
What this interaction means in plain words
Brexpiprazole and Fentanyl intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and antipsychotic sedation.
What to do
Use only when alternatives are inadequate, start with the lowest fentanyl dose, and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Fentanyl intranasal?
MediHelp rates the interaction as major. Brexpiprazole and Fentanyl intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intranasal fentanyl with brexpiprazole can cause additive sedation and respiratory depression. Cognitive and psychomotor impairment may also be amplified.
How serious is the interaction between Brexpiprazole and Fentanyl intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when alternatives are inadequate, start with the lowest fentanyl dose, and monitor for sedation and respiratory depression.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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