Drug interactions
Brexpiprazole + Fentanyl iontophoretic transdermal system
Severity: Major
Brexpiprazole and Fentanyl iontophoretic transdermal system: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole may increase the sedation and respiratory depression caused by fentanyl delivered through an iontophoretic system. Impaired alertness and coordination can result.
What this interaction means in plain words
Brexpiprazole and Fentanyl iontophoretic transdermal system can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression from opioid and antipsychotic activity.
What to do
Reserve the combination for patients without adequate alternatives and monitor closely for oversedation and slowed breathing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Fentanyl iontophoretic transdermal system?
MediHelp rates the interaction as major. Brexpiprazole and Fentanyl iontophoretic transdermal system can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexpiprazole may increase the sedation and respiratory depression caused by fentanyl delivered through an iontophoretic system. Impaired alertness and coordination can result.
How serious is the interaction between Brexpiprazole and Fentanyl iontophoretic transdermal system?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients without adequate alternatives and monitor closely for oversedation and slowed breathing.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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