Drug interactions
Brexpiprazole + Fentanyl transmucosal
Severity: Major
Brexpiprazole and Fentanyl transmucosal: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transmucosal fentanyl combined with brexpiprazole may cause additive sedation and respiratory depression. The rapid onset of transmucosal fentanyl can make oversedation abrupt.
What this interaction means in plain words
Brexpiprazole and Fentanyl transmucosal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid and antipsychotic effects.
What to do
Use only if alternatives are inadequate, titrate fentanyl cautiously, and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Fentanyl transmucosal?
MediHelp rates the interaction as major. Brexpiprazole and Fentanyl transmucosal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Transmucosal fentanyl combined with brexpiprazole may cause additive sedation and respiratory depression. The rapid onset of transmucosal fentanyl can make oversedation abrupt.
How serious is the interaction between Brexpiprazole and Fentanyl transmucosal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if alternatives are inadequate, titrate fentanyl cautiously, and monitor for sedation and respiratory depression.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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