Drug interactions
Brexpiprazole + Flurazepam
Severity: Moderate
Brexpiprazole and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a long-acting benzodiazepine hypnotic with brexpiprazole can increase sedation, impair coordination and raise fall risk, with residual daytime effects from flurazepam's active metabolite. Respiratory depression is possible at high doses.
What this interaction means in plain words
Brexpiprazole and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and antipsychotic sedative effects.
What to do
Use the lowest flurazepam dose and monitor for oversedation and falls, especially in older adults. Consider a shorter-acting hypnotic if next-day impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Flurazepam?
MediHelp rates the interaction as moderate. Brexpiprazole and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a long-acting benzodiazepine hypnotic with brexpiprazole can increase sedation, impair coordination and raise fall risk, with residual daytime effects from flurazepam's active metabolite. Respiratory depression is possible at high doses.
How serious is the interaction between Brexpiprazole and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest flurazepam dose and monitor for oversedation and falls, especially in older adults. Consider a shorter-acting hypnotic if next-day impairment occurs.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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