Drug interactions
Brexpiprazole + Gabapentin
Severity: Moderate
Brexpiprazole and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the central nervous system, and gabapentin can add to respiratory depression when combined with other CNS depressants. Sedation, dizziness and impaired psychomotor function may be greater with the combination.
What this interaction means in plain words
Brexpiprazole and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Gabapentin belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depressant effects (pharmacodynamic).
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, especially in older adults or those with lung disease. Take extra care when other CNS depressants are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Gabapentin
Frequently asked questions
Can I take Brexpiprazole with Gabapentin?
MediHelp rates the interaction as moderate. Brexpiprazole and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the central nervous system, and gabapentin can add to respiratory depression when combined with other CNS depressants. Sedation, dizziness and impaired psychomotor function may be greater with the combination.
How serious is the interaction between Brexpiprazole and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, especially in older adults or those with lung disease. Take extra care when other CNS depressants are present.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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