Drug interactions
Brexpiprazole + Isoniazid
Severity: Minor
Brexpiprazole and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may inhibit CYP3A4 and to a lesser extent CYP2D6, potentially raising brexpiprazole exposure. The effect is likely small as isoniazid is only a weak inhibitor.
What this interaction means in plain words
Brexpiprazole and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak inhibition of CYP3A4 and CYP2D6 by isoniazid, reducing brexpiprazole clearance.
What to do
Monitor for sedation, akathisia and orthostatic hypotension. Reduce the brexpiprazole dose if adverse effects occur, especially if a stronger CYP2D6 or CYP3A4 inhibitor is also taken.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Isoniazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Isoniazid?
MediHelp rates the interaction as minor. Brexpiprazole and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid may inhibit CYP3A4 and to a lesser extent CYP2D6, potentially raising brexpiprazole exposure. The effect is likely small as isoniazid is only a weak inhibitor.
How serious is the interaction between Brexpiprazole and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, akathisia and orthostatic hypotension. Reduce the brexpiprazole dose if adverse effects occur, especially if a stronger CYP2D6 or CYP3A4 inhibitor is also taken.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
