Drug interactions
Brexpiprazole + Lamotrigine
Severity: Minor
Brexpiprazole and Lamotrigine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may cause somnolence and dizziness, and they are often used together in bipolar disorder. Additive sedation can occur, particularly during dose changes.
What this interaction means in plain words
Brexpiprazole and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Lamotrigine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Monitor for drowsiness and dizziness when starting or adjusting either drug. Usually no dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brexpiprazole
Other interactions of Lamotrigine
Frequently asked questions
Can I take Brexpiprazole with Lamotrigine?
MediHelp rates the interaction as minor. Brexpiprazole and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs may cause somnolence and dizziness, and they are often used together in bipolar disorder. Additive sedation can occur, particularly during dose changes.
How serious is the interaction between Brexpiprazole and Lamotrigine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and dizziness when starting or adjusting either drug. Usually no dose change is needed.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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