Drug interactions
Brexpiprazole + Lorcaserin
Severity: Minor
Brexpiprazole and Lorcaserin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin was a CYP2D6 inhibitor that could modestly raise brexpiprazole exposure. Both agents also have serotonergic or CNS effects, though no clear clinical interaction is established, and lorcaserin has been withdrawn from the market.
What this interaction means in plain words
Brexpiprazole and Lorcaserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP2D6 inhibition by lorcaserin may reduce brexpiprazole metabolism.
What to do
No routine dose change is needed; monitor for brexpiprazole adverse effects such as akathisia and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Lorcaserin?
MediHelp rates the interaction as minor. Brexpiprazole and Lorcaserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorcaserin was a CYP2D6 inhibitor that could modestly raise brexpiprazole exposure. Both agents also have serotonergic or CNS effects, though no clear clinical interaction is established, and lorcaserin has been withdrawn from the market.
How serious is the interaction between Brexpiprazole and Lorcaserin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for brexpiprazole adverse effects such as akathisia and sedation.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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