Drug interactions
Brexpiprazole + Lumacaftor / ivacaftor
Severity: Moderate
Brexpiprazole and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and can lower brexpiprazole concentrations, risking loss of therapeutic effect.
What this interaction means in plain words
Brexpiprazole and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by lumacaftor increases brexpiprazole clearance.
What to do
Monitor clinical response and increase brexpiprazole dose gradually over 1 to 2 weeks if needed. Reduce it again if lumacaftor/ivacaftor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Brexpiprazole and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and can lower brexpiprazole concentrations, risking loss of therapeutic effect.
How serious is the interaction between Brexpiprazole and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase brexpiprazole dose gradually over 1 to 2 weeks if needed. Reduce it again if lumacaftor/ivacaftor is stopped.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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