Drug interactions
Brexpiprazole + Metformin-sitagliptin
Severity: Moderate
Brexpiprazole and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole can cause hyperglycemia and weight gain, which may reduce glycemic control in patients on metformin and sitagliptin. The effect is usually modest but can be significant in patients with diabetes.
What this interaction means in plain words
Brexpiprazole and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-related metabolic effects and insulin resistance.
What to do
Monitor glucose and HbA1c at baseline and during treatment. Intensify antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Brexpiprazole and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole can cause hyperglycemia and weight gain, which may reduce glycemic control in patients on metformin and sitagliptin. The effect is usually modest but can be significant in patients with diabetes.
How serious is the interaction between Brexpiprazole and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c at baseline and during treatment. Intensify antidiabetic therapy if control worsens.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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