Drug interactions
Brexpiprazole + Midazolam intranasal
Severity: Moderate
Brexpiprazole and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a potent sedative and brexpiprazole also has sedating properties. Combined use can deepen sedation and increase the risk of hypoventilation or airway compromise.
What this interaction means in plain words
Brexpiprazole and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system and respiratory depression.
What to do
Use the lowest effective midazolam dose and monitor respiratory rate, oxygen saturation and level of consciousness after administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Midazolam intranasal?
MediHelp rates the interaction as moderate. Brexpiprazole and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam is a potent sedative and brexpiprazole also has sedating properties. Combined use can deepen sedation and increase the risk of hypoventilation or airway compromise.
How serious is the interaction between Brexpiprazole and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose and monitor respiratory rate, oxygen saturation and level of consciousness after administration.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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