Drug interactions
Brexpiprazole + Nafcillin
Severity: Moderate
Brexpiprazole and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may reduce brexpiprazole levels during prolonged therapy, though the effect is less well characterized than with rifampin.
What this interaction means in plain words
Brexpiprazole and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by nafcillin increases brexpiprazole metabolism.
What to do
Monitor for loss of psychiatric symptom control during a nafcillin course and adjust brexpiprazole dose according to response. Reassess the dose after nafcillin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Nafcillin?
MediHelp rates the interaction as moderate. Brexpiprazole and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may reduce brexpiprazole levels during prolonged therapy, though the effect is less well characterized than with rifampin.
How serious is the interaction between Brexpiprazole and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychiatric symptom control during a nafcillin course and adjust brexpiprazole dose according to response. Reassess the dose after nafcillin is stopped.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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