Drug interactions
Brexpiprazole + Netupitant / palonosetron
Severity: Moderate
Brexpiprazole and Netupitant / palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant is a moderate CYP3A4 inhibitor and may raise brexpiprazole exposure. The effect after a single dose is likely modest, but it is more relevant when a CYP2D6 inhibitor is also present.
What this interaction means in plain words
Brexpiprazole and Netupitant / palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated brexpiprazole metabolism by netupitant.
What to do
Monitor for akathisia, sedation and hypotension. Reduce brexpiprazole to a quarter of the usual dose if a CYP2D6 inhibitor is also being used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Netupitant / palonosetron?
MediHelp rates the interaction as moderate. Brexpiprazole and Netupitant / palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant is a moderate CYP3A4 inhibitor and may raise brexpiprazole exposure. The effect after a single dose is likely modest, but it is more relevant when a CYP2D6 inhibitor is also present.
How serious is the interaction between Brexpiprazole and Netupitant / palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for akathisia, sedation and hypotension. Reduce brexpiprazole to a quarter of the usual dose if a CYP2D6 inhibitor is also being used.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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