Drug interactions
Brexpiprazole + Olanzapine
Severity: Moderate
Brexpiprazole and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are atypical antipsychotics causing sedation, orthostatic hypotension and metabolic effects. The combination increases cumulative adverse effect burden.
What this interaction means in plain words
Brexpiprazole and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and receptor-mediated adverse effects (pharmacodynamic).
What to do
Avoid antipsychotic polypharmacy where possible. If combined, monitor sedation, blood pressure, weight, glucose and lipids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Olanzapine
Frequently asked questions
Can I take Brexpiprazole with Olanzapine?
MediHelp rates the interaction as moderate. Brexpiprazole and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are atypical antipsychotics causing sedation, orthostatic hypotension and metabolic effects. The combination increases cumulative adverse effect burden.
How serious is the interaction between Brexpiprazole and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible. If combined, monitor sedation, blood pressure, weight, glucose and lipids.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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