Drug interactions
Brexpiprazole + Olopatadine intranasal
Severity: Moderate
Brexpiprazole and Olopatadine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause drowsiness, which may add to the sedation caused by brexpiprazole. Combined use may impair alertness and psychomotor performance.
What this interaction means in plain words
Brexpiprazole and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from antihistaminic and antipsychotic sedative effects.
What to do
Counsel patients about daytime drowsiness and driving risk, and consider a less sedating alternative if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Olopatadine intranasal?
MediHelp rates the interaction as moderate. Brexpiprazole and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal olopatadine can cause drowsiness, which may add to the sedation caused by brexpiprazole. Combined use may impair alertness and psychomotor performance.
How serious is the interaction between Brexpiprazole and Olopatadine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about daytime drowsiness and driving risk, and consider a less sedating alternative if impairment occurs.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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