Drug interactions
Brexpiprazole + Orphenadrine
Severity: Moderate
Brexpiprazole and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is a sedating anticholinergic muscle relaxant that may add to the drowsiness caused by brexpiprazole. Additive anticholinergic effects such as confusion, dry mouth and urinary retention can also occur, particularly in older adults.
What this interaction means in plain words
Brexpiprazole and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor for sedation, confusion and anticholinergic effects, especially in older patients. Consider a lower orphenadrine dose or an alternative muscle relaxant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Orphenadrine?
MediHelp rates the interaction as moderate. Brexpiprazole and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is a sedating anticholinergic muscle relaxant that may add to the drowsiness caused by brexpiprazole. Additive anticholinergic effects such as confusion, dry mouth and urinary retention can also occur, particularly in older adults.
How serious is the interaction between Brexpiprazole and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and anticholinergic effects, especially in older patients. Consider a lower orphenadrine dose or an alternative muscle relaxant.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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