Drug interactions
Brexpiprazole + Pimozide
Severity: Moderate
Brexpiprazole and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on dopamine receptors and cause sedation, so combined use can increase drowsiness, extrapyramidal symptoms, and the theoretical risk of neuroleptic malignant syndrome. Pimozide also prolongs the QT interval, which adds a cardiac concern with another antipsychotic.
What this interaction means in plain words
Brexpiprazole and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive dopamine receptor antagonism and sedation, with additive QT effects.
What to do
Avoid antipsychotic combination where possible and use the lowest effective doses. Monitor for sedation, movement disorders, and obtain an ECG if risk factors for QT prolongation exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Pimozide?
MediHelp rates the interaction as moderate. Brexpiprazole and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on dopamine receptors and cause sedation, so combined use can increase drowsiness, extrapyramidal symptoms, and the theoretical risk of neuroleptic malignant syndrome. Pimozide also prolongs the QT interval, which adds a cardiac concern with another antipsychotic.
How serious is the interaction between Brexpiprazole and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic combination where possible and use the lowest effective doses. Monitor for sedation, movement disorders, and obtain an ECG if risk factors for QT prolongation exist.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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