Drug interactions
Brexpiprazole + Protriptyline
Severity: Moderate
Brexpiprazole and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant that can cause sedation, anticholinergic effects, orthostatic hypotension and QT prolongation. Combining it with brexpiprazole may increase these effects, and protriptyline's CYP2D6 inhibition may be minor but could raise brexpiprazole exposure.
What this interaction means in plain words
Brexpiprazole and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotensive effects, with possible weak CYP2D6 competition.
What to do
Monitor for sedation, orthostatic hypotension and anticholinergic effects, and consider an ECG in patients with cardiac risk. Adjust doses according to tolerance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Protriptyline?
MediHelp rates the interaction as moderate. Brexpiprazole and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic antidepressant that can cause sedation, anticholinergic effects, orthostatic hypotension and QT prolongation. Combining it with brexpiprazole may increase these effects, and protriptyline's CYP2D6 inhibition may be minor but could raise brexpiprazole exposure.
How serious is the interaction between Brexpiprazole and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and anticholinergic effects, and consider an ECG in patients with cardiac risk. Adjust doses according to tolerance.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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