Drug interactions
Brexpiprazole + Quazepam
Severity: Moderate
Brexpiprazole and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a benzodiazepine hypnotic, and together with brexpiprazole it can increase sedation, psychomotor impairment and the risk of falls. Respiratory depression is more likely at high doses or in vulnerable patients.
What this interaction means in plain words
Brexpiprazole and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and antipsychotic sedation.
What to do
Use the lowest effective quazepam dose and monitor for oversedation and impaired coordination. Avoid in patients with respiratory compromise or increased fall risk when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Quazepam?
MediHelp rates the interaction as moderate. Brexpiprazole and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a benzodiazepine hypnotic, and together with brexpiprazole it can increase sedation, psychomotor impairment and the risk of falls. Respiratory depression is more likely at high doses or in vulnerable patients.
How serious is the interaction between Brexpiprazole and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective quazepam dose and monitor for oversedation and impaired coordination. Avoid in patients with respiratory compromise or increased fall risk when possible.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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