Drug interactions
Brexpiprazole + Schisandra
Severity: Moderate
Brexpiprazole and Schisandra: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Schisandra constituents inhibit CYP3A4 and may raise brexpiprazole concentrations to a modest degree. The effect is variable and depends on the product used.
What this interaction means in plain words
Brexpiprazole and Schisandra can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Schisandra lignans inhibit CYP3A4, reducing brexpiprazole clearance.
What to do
Monitor for sedation, akathisia and orthostatic hypotension, and consider avoiding the herb. If the patient also takes a CYP2D6 inhibitor, consider reducing the brexpiprazole dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Schisandra?
MediHelp rates the interaction as moderate. Brexpiprazole and Schisandra can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Schisandra constituents inhibit CYP3A4 and may raise brexpiprazole concentrations to a modest degree. The effect is variable and depends on the product used.
How serious is the interaction between Brexpiprazole and Schisandra?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, akathisia and orthostatic hypotension, and consider avoiding the herb. If the patient also takes a CYP2D6 inhibitor, consider reducing the brexpiprazole dose.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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