Drug interactions
Brexpiprazole + Zaleplon
Severity: Moderate
Brexpiprazole and Zaleplon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole may cause somnolence, and combined with zaleplon sedation and impaired alertness may increase. The interaction is usually manageable.
What this interaction means in plain words
Brexpiprazole and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Zaleplon belongs to Central Nervous System.
Why it happens
Additive CNS depression via different receptor mechanisms.
What to do
Use the lowest effective zaleplon dose and monitor for daytime sedation and dizziness. Counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Zaleplon?
MediHelp rates the interaction as moderate. Brexpiprazole and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole may cause somnolence, and combined with zaleplon sedation and impaired alertness may increase. The interaction is usually manageable.
How serious is the interaction between Brexpiprazole and Zaleplon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective zaleplon dose and monitor for daytime sedation and dizziness. Counsel on driving.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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