Drug interactions
Brigatinib + Desogestrel-ethinyl estradiol
Severity: Major
Brigatinib and Desogestrel-ethinyl estradiol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib may induce CYP3A4 and reduce concentrations of hormonal contraceptives, risking contraceptive failure. Because brigatinib can harm the fetus, loss of contraceptive efficacy is clinically important.
What this interaction means in plain words
Brigatinib and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Desogestrel-ethinyl estradiol belongs to Endocrine.
Why it happens
Induction of CYP3A4 by brigatinib increases the metabolism of ethinyl estradiol and progestin.
What to do
Use an effective non-hormonal contraceptive during treatment and for at least 4 months after the last brigatinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as major. Brigatinib and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brigatinib may induce CYP3A4 and reduce concentrations of hormonal contraceptives, risking contraceptive failure. Because brigatinib can harm the fetus, loss of contraceptive efficacy is clinically important.
How serious is the interaction between Brigatinib and Desogestrel-ethinyl estradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive during treatment and for at least 4 months after the last brigatinib dose.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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