Drug interactions
Brigatinib + Clarithromycin
Severity: Major
Brigatinib and Clarithromycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin raises brigatinib exposure through strong CYP3A inhibition, increasing risk of adverse effects such as pulmonary toxicity, hypertension, bradycardia and pancreatic enzyme elevations.
What this interaction means in plain words
Brigatinib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Clarithromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of brigatinib.
What to do
Avoid if possible. If unavoidable, reduce brigatinib dose by about half and resume the prior dose after stopping clarithromycin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Clarithromycin?
MediHelp rates the interaction as major. Brigatinib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin raises brigatinib exposure through strong CYP3A inhibition, increasing risk of adverse effects such as pulmonary toxicity, hypertension, bradycardia and pancreatic enzyme elevations.
How serious is the interaction between Brigatinib and Clarithromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce brigatinib dose by about half and resume the prior dose after stopping clarithromycin.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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