Drug interactions
Brigatinib + Carbamazepine
Severity: Major
Brigatinib and Carbamazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can reduce brigatinib exposure and efficacy, and brigatinib may induce CYP3A4 and lower carbamazepine levels, risking breakthrough seizures.
What this interaction means in plain words
Brigatinib and Carbamazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP3A4, lowering brigatinib levels, and brigatinib is a CYP3A4 inducer in vitro that may reduce carbamazepine.
What to do
Avoid strong CYP3A inducers with brigatinib and use a non-inducing anticonvulsant; if unavoidable, monitor carbamazepine levels and tumor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Carbamazepine?
MediHelp rates the interaction as major. Brigatinib and Carbamazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine can reduce brigatinib exposure and efficacy, and brigatinib may induce CYP3A4 and lower carbamazepine levels, risking breakthrough seizures.
How serious is the interaction between Brigatinib and Carbamazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A inducers with brigatinib and use a non-inducing anticonvulsant; if unavoidable, monitor carbamazepine levels and tumor response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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