Drug interactions
Brigatinib + Fentanyl
Severity: Moderate
Brigatinib and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib may induce CYP3A4 and lower fentanyl concentrations, potentially reducing analgesia. Withdrawal or uncontrolled pain may occur, and stopping brigatinib later could raise fentanyl levels and cause toxicity.
What this interaction means in plain words
Brigatinib and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Fentanyl belongs to Musculoskeletal.
Why it happens
CYP3A4 induction by brigatinib increases fentanyl metabolism.
What to do
Monitor analgesic response and adjust fentanyl dose if needed. If brigatinib is discontinued, watch for opioid toxicity and reduce the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Fentanyl?
MediHelp rates the interaction as moderate. Brigatinib and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brigatinib may induce CYP3A4 and lower fentanyl concentrations, potentially reducing analgesia. Withdrawal or uncontrolled pain may occur, and stopping brigatinib later could raise fentanyl levels and cause toxicity.
How serious is the interaction between Brigatinib and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and adjust fentanyl dose if needed. If brigatinib is discontinued, watch for opioid toxicity and reduce the dose accordingly.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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